Xenopus, an ideal model system to study vertebrate left-right asymmetry
نویسندگان
چکیده
منابع مشابه
Left-right asymmetry in vertebrate development.
Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and ...
متن کاملCilia are at the heart of vertebrate left-right asymmetry.
Handed asymmetry of the shape and position of the internal organs is found in all vertebrates, and is essential for normal cardiac development. Recent genetic and embryological experiments in mouse embryos have demonstrated that left-right asymmetry is established by directional flow of extraembryonic fluid surrounding the node, which is driven by motile monocilia.
متن کاملIntraciliary calcium oscillations initiate vertebrate left-right asymmetry
BACKGROUND Bilateral symmetry during vertebrate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid. However, how ciliary motility is perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial. Previous work has indicated that sensory cilia and polycystin-2 (Pkd2), a cation...
متن کاملOrganizer induction determines left-right asymmetry in Xenopus.
Vertebrates appear bilaterally symmetrical but have considerable left-right (LR) asymmetry in the anatomy and placement of internal organs such as the heart. Although a number of asymmetrically expressed genes are known to affect LR patterning, both the initial source of asymmetry and the mechanism that correctly orients the LR axis remain controversial. In this study, we show that the inductio...
متن کاملVertebrate left-right development
Significant biological asymmetries range from the differentiation of sides within a single cell to the establishment of embryonic pattern across large fields of cells in multicellular organisms. One of the most intriguing biological asymmetries is left-right asymmetry in vertebrates. All vertebrates display a number of structures that are asymmetric along the left-right geometric body axis. The...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2009
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21855